Mentype® AMLplex

Product code: 45-31220
Producer: Biotype GmbH
Kit detecting a panel of eleven gene fusions associated with acute myeloid leukemia in a single PCR reaction.

More detailed product information

Mentype® AMLplexQS is a tool for screening 11 gene fusions (34 transcriptional variants) associated with acute myeloid leukemia (AML) in a single multiplex-PCR mix. Each PCR reaction contains an inhibitory internal PCR control and quality control of the amplified cDNA.

The kit is based on RNA isolated from blood or bone marrow transcribed into cDNA, which is amplified using the kit and analyzed by capillary electrophoresis on ABI sequencers.


Gene fusion  Aberration Variants
AML1-ETO  t(8;21)(q22;q22) -
BCR-ABL  t(9;22)(q34;q11) e1a2/3, b2a2/3, b3a2/3
CALM-AF10  t(10;11)(p13;q14) AF10_240-CALM_1987
CBFB-MYH11  inv(16)(p13;q22) Typ A, B, C, D, E, F, G, H, I, J
DEK-CAN  t(6;9)(p23;q34) -
MLL-AF6  t(6;11)(q27;q23) -
MLL-AF9  t(9;11)(p22;q23) 6A_(THP1), 7A_(10A),
    8A_(MM6), 6B_(9B)
MLL-ELL  t(11;19)(q23;p13.1) e10e2/3
MLL-PTD  tandem duplication e9e3, e10e3, e11e3
NPM1-MLF1  t(3;5)(q25.1;q34) -
PML-RARA  t(15;17)(q22;q21) bcr1 (PR-L), bcr2 (PR-V),
    bcr3 (PR-S)

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