Digital MLPA is a patented technology of MRC Holland that combines the advantages of classic MLPA methodology and Next-generation sequencing.
Enables reliable and efficient CNV analysis through 1000 probes.
The evaluation of the results is made possible by the unique Coffalyser digitalMLPA software.
Principle of the method: https://support.mrcholland.com/kb/articles/video-what-is-digitalmlpa
NXtec D006-A1 Multiple Myeloma enables using digitalMLPA technology detection of deletions or duplications in key genes and chromosomal regions in multiple myeloma using more than 600 probes that target:
- chromosomal arms with recurrent CNVs including: 1p, 1q, 13q, 17p
- chromosomal regions to detect aneuploidy and ploidy status (e.g. hyperdiploidy)
- genes of emerging importance: BCMA, CRBN, GPDC5D, FcRH5, IKZF1/3, IRF4, MYC, RPL5, SLAMF7
- BRAF V600E mutation
The kit is compatible with Ilumina sequencers.
Actual product information and documents can be found on the MRC Holland website.
