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CISENDO or Human CDO1 and CELF4 Gene Methylation Detection Kit（Real-time PCR）is a test for early detection of endometrial cancer based on the measurement of methylation status of target genes, which in this case are CDO1 and CELF4.
It is a non-invasive test where the input material is cervical smear preservation medium.
The whole workflow, which takes less than 8 hours, consists of five steps: 1. cervical smear, 2. DNA extraction from the medium, 3. bisulfite conversion, 4. rt-PCR, 5. analysis of the results.
The output of the test is a "high risk" or "low risk" result, where high risk means that according to the test, the woman has been found to have endometrial cancer and further testing is needed, and low risk means no cancer has been found and the woman is recommended for regular follow-up.
The manufacturer supplies a comprehensive diagnostic scheme for the management of the patient.
The test achieves the following parameters:
Sensitivity - 88%
Specificity - 92%
The test is compatible with all commonly used rt-PCR instruments and is CE-IVD certified.
For more information, please contact us by e-mail: diagnostika@pentagen.cz