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CISOVA or Human CDO1 and HOXA9 Gene Methylation Detection kit（Real-time PCR）is a test for early detection of ovarian cancer and is based on the principle of measuring the methylation status of target genes, which in this case are CDO1 and HOXA9.
The input material is blood, which in the case of ovarian cancer contains free tumour DNA.
The whole workflow, which takes less than 8 hours, consists of five steps: 1. blood collection, 2. DNA extraction from blood, 3. bisulfite conversion, 4. rt-PCR, 5. analysis of the results.
The output of the test is a "high risk" or "low risk" result, where high risk means that according to the test, the woman has been found to have ovarian cancer and further testing is needed, and low risk means no cancer has been found and the woman is recommended for regular follow-up.
The manufacturer supplies a comprehensive diagnostic scheme for the management of the patient.
The test achieves the following parameters:
Sensitivity - 92%
Specificity - 91%
The test is compatible with all commonly used rt-PCR instruments and is CE-IVD certified.
For more information, please contact us by e-mail: diagnostika@pentagen.cz