CleanPlex® ready-to-use panels

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More detailed product information

NGS panels for variant detection in somatic and germline samples using patented CleanPlex® technology.

CleanPlex® is a highly scalable and sensitive NGS amplicon sequencing technology. It features an advanced proprietary multiplex PCR primer design algorithm, an exceptionally uniform multiplex PCR amplification chemistry and an innovative, patented background cleaning chemistry.

High amplification uniformity and low PCR background noise for accurate variant calling
Single-tube and 3-hour workflow with minimal hands-on time for easy automation
Compatible with difficult samples (e.g. degraded FFPE DNA, DNA from wastewater, etc.)
Extreme sensitivity (down to single cell level direct amplification)
Excellent panel size scalability from a few to over 20,000 amplicons in a single multiplex PCR pool
Compatible with major sequencing platforms (Illumina, Ion Torrent, MGI DNBSeq, Element Biosciences, Oxford Nanopore, etc.)
Detection of single nucleotide variants (SNVs), small insertions and deletions (Indels), copy number variations (CNVs), gene fusions / splice variants, gene expression level, tumor mutational burden (TMB), microsatellite instability (MSI), internal tandem duplication (ITD), etc.

Available CleanPlex ready-to-use cancer panels:

916001, 916002, 916103	8, 96, 384 rxn	CleanPlex OncoZoom Cancer Hotspot Panel	2900+ hotspot regions of 65 oncogenes and tumor suppressor genes
916073, 916074, 916075	6, 96, 384 rxn	CleanPlex Tumor Mutational Burden 500 Gene Panel	516 genes associated with major solid tumor types, assessment of tumor mutational burden
916112, 916113	8, 96 rxn	CleanPlex BRCA1 & BRCA2 Panel	all exonic regions and 20 bp of flanking intronic sequences of BRCA1 and BRCA2
916114, 916115	8, 96 rxn	CleanPlex Hereditary Cancer Panel	37 genes, 2 hotspot mutations in the BRCA1 3’ UTR and Boland inversion in MSH2
930017, 930015, 930013	8, 96, 384 reakcí	CleanPlex Comprehensive Hereditary Cancer Panel	germinální varianty nebo mutace v 88 genech spojených s hereditárními nádorovými syndromy
916008, 916104, 916105, 916009, 916106	8, 16, 48, 96, 384 rxn	CleanPlex TP53 Panel	all exonic regions and flanking intronic sequences of TP53

In addition to ready-to-use panels, Paragon Genomics also offers CleanPlex Custom NGS Panels powered by CleanPlex Technology and ParagonDesigner (advanced multiplex PCR primer design software). For more information on these products, please visit the manufacturer's website.

For more information, please contact us by e-mail: diagnostika@pentagen.cz