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Digital MLPA is a patented technology of MRC Holland that combines the advantages of classic MLPA methodology and Next-generation sequencing.
Enables reliable and efficient CNV analysis through 1000 probes.
The evaluation of the results is made possible by the unique Coffalyser digitalMLPA software
Principle of the method: https://support.mrcholland.com/kb/articles/video-what-is-digitalmlpa
SALSA digitalMLPA probemix D001-D1 Hereditary Cancer Panel 1 allows detection of CNVs in genes associated with hereditary predisposition to breast, ovarian, colorectal, gastric, prostate, pancreatic or endometrial cancer, or melanoma.
The panel consists of 723 probes, including 575 probes for 28 genes associated with hereditary cancer syndromes.
The kit is compatible with Illumina's sequencers and is intended for research use only (RUO).
List of genes included: MUTYH, EPCAM, MSH2, MSH6, BARD1, MLH1, BAP1, MITF, APC, PMS2, NBN, CDKN2A, BMPR1A, PTEN, ATM, CDK4, POLE, BRCA1, BRCA2, SCG5/GREM1, PALB2, CDH1, TP53, RAD51D, RAD51C, BRIP1, SMAD4, STK11, CHEK2
Actual product information and documents can be found on the MRC Holland website.
For more information, please contact us by e-mail: diagnostika@pentagen.cz